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VIOXX is used for relief of the signs and symptoms of osteoarthritis, relief of the signs and symptoms of rheumatoid arthritis in adults, relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older and who weigh 10 kg (22 lbs) or more, for the management of acute pain in adults, for the treatment of primary dysmenorrhea and for the acute treatment of migraine attacks with or without aura in adults.

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VioxxThe safety and effectiveness of VIOXX have not been established for cluster headache, which is present in an older, predominantly male, population. Itis a COX-2 inhibitor that was originally approved by to be used for pain relief and reducing inflammation for patients with osteoarthritis, as well as for menstrual pain. It was later approved to be used for rheumatoid arthritis.

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Rofecoxib is a cyclooxygenase 2–selective, nonsteroidal anti-inflammatory drug (NSAID) that was approved by FDA in May 1999 for the relief of the signs and symptoms of osteoarthritis, for the management of acute pain in adults, and for the treatment of menstrual symptoms, and was later approved for the relief of the signs and symptoms of rheumatoid arthritis in adults and children.

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, particularly the pain of osteoarthritis and menstrual cramps. Prostaglandins are chemicals that are important in promoting inflammation and its signs–pain, fever, swelling and tenderness. Rofecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase- 2) and thereby reduces the amounts of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness also are reduced. Rofecoxib is similar to celecoxib (Celebrex). Both drugs differ from other NSAIDs in that they cause less irritation and ulceration of the stomach and intestine (at least during short-term treatment), and they do not interfere with the clotting of blood

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